Differences between the E & F versions were mostly changes in nose armament layout, with staggered cheek guns being implemented, and a change in the bombardier's glass nose, although this would vary occasionally between machines, with a a number of sub-types and adaptations being fitted. Other changes included engine cowls with rounder forward radius, paddle-blade prop blades and strengthened undercarriage the allowed the internal bomb load to double from 4000lb to 8000lb. Includes markings for:

• B-17F-10-B0, s/n 41-24485, DF-A, 324th BS / 91st BG, Bassingbourn, UK, May 1943 "Memphis Belle"
• B-17F-50-B0, s/n 42-5360 VK-N, 358th BS / 303rd BG, Molesworth, UK, late 1943
• "Old Faithful"