In the spring of 1941, the release of the He 111H-6 subtype began, which had more powerful Jumo 211F engines than the original He-111H. The main differences were new wide-bladed propellers, individual exhaust manifolds, in addition to significantly strengthened protective weaponry.

He 111H-6 was used as a night and day bomber, however, due to the expansion of the theaters of war including those over water surfaces, it was quite often used as a torpedo aircraft. It was used in this role both in the European and in the North African theater, with considerable success. The He 111H-6 was a significant threat to naval vessels as it had a good level of aiming speed and precision, and its armament of two torpedoes significantly increased the chances of hitting the target.